Clinical observations were made on 251 cases of pyodermas at the Department of Dermatology. Kyungpook University Hospital from 1968 to 1972. Especially noteworthy is the application of josamycin to 41 cases of pyodermas to observe its therapeutic effects.
Since 1968, the frequency of pyodermas has shown an annual increase. The ratio between male and female was 1.4 : 1, gradually changing from 2.3 : I in 1968 to an almost balanced incidence in 1972.
The age of onset differed with types of disease, but 76. 2% of all cases occurred before the age of 15. The outbreaks of impetigo bullosa and impetigo vulgaris were found to be affected by season, the highest prevalence being in summer. Seasonal occurrence of all cases was found to be 45.5% in summer and 24.3% in fall with no noticeable change observed in spring and winter.
Predilection sites of the disease differed according to the type of the disease but all types showed a marked predilection for the exposed areas as against the covered areas (4 times).
Sensitivity of causative organisms to antibiotics was found to be fairly high to cloxacillin, novobiocin and ampicillin, and relative to kanamycin, streptomycin and doxycycline but all tested cases showed resistance to tetracycline, chlortetracycline and oxytetracycline.
Josamycin was effective in all types of pyodermas, and was dramtically so in impetigo bullosa of which pustules disappeared within 3 or 5 days of treatment. Two out of 41 cases complained of abdominal pain and weakness. The sensitivity of the causative organisms of all types of pyodermas to josamycin was 83.3%.
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